| Date | Time | Opponent | Location | Score |
| 4/2/08 | 4:30 p.m. | St. James School | Away | Mercersburg 6-St. James 5 |
| 4/4/08 | 6:00 p.m. | Hempfield Lacrosse Club | Away | Hempfield 12-Mercersburg 1 |
| 4/9/08 | 5:45 p.m. | St. John's Catholic Prep | Home | CANCELLED |
| 4/12/08 | 1:00 p.m. | Highland School | Away | Highland 8-Mercersburg 1 |
| 4/16/08 | 6:15 p.m. | Carlisle Lacrosse Club | Away | Carlisle 6-Mercersburg 2 |
| 4/19/08 | 1:00 p.m. | Smithsburg Lacrosse Club | Home | Smithsburg 11-Mercersburg 2 |
| 4/23/08 | 4:30 p.m. | Smithsburg Lacrosse Club | Away | CANCELLED |
| 4/26/08 | 1:00 p.m. | Highland School | Home | CANCELLED |
| 4/30/08 | 5:00 p.m. | St. John's Catholic Prep | Home | St. John's Catholic Prep 5-Mercersburg 3 |
| 5/4/08 | 1:45 p.m. | Wyoming Seminary | Home | Mercersburg 4-Wyoming Seminary 3 |
| 5/8/08 | 6:00 p.m. | Cumberland Valley Lacrosse Club | Home | CANCELLED |
| 5/10/08 | 10:00 a.m. | Chambersburg Tournament vs St. James School | Away | |
| 5/10/08 | 11:15 a.m. | Chambersburg Tournament vs Spring Grove | Away | |
| 5/10/08 | 12:15 p.m. | Chambersburg Tournament vs Carlisle | Away | CANCELLED |
| 5/13/08 | 5:00 p.m. | St. James School | Home | St. James 4-Mercersburg 2 |
| 5/16/08 | 5:30 p.m. | Chambersburg Lacrosse Club | Away | Chambersburg 12-Mercersburg 4 |